Category: DNA

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Undoing millennia of barley selection

Generations of beer-loving farmers have bred seed dormancy almost entirely out of barley, so that the grains will readily germinate in the malthouse. Unfortunately, that means that malting varieties are sometimes prone to jumping the gun and sprouting before harvest, while the crop is still standing in the field. That means that the grain cannot be used to make beer. Not a good thing.

Fortunately, a PhD student in Australia, a land well known for its love of the amber nectar, has compared the barley genome with that of Arabidopsis and identified some bits which may contain previously unknown dormancy genes. Should a negative effect on pre-harvest sprouting be confirmed in the field – and trials are under way – breeders could use markers for these genes to help them select genotypes which will only sprout where it would do the most good: in the maltings.

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Durum wheat erosion

If there’s a dominant meta-narrative in agricultural biodiversity circles it is that modern breeding programmes relentlessly decrease the genetic diversity of crops, increasing yields and quality but also, as new varieties displace landraces and older varieties in farmers’ fields, depleting the very resource on which they are dependent for continued success. But actually there’s not really that much in the way of hard figures on this process. So a recent paper on what breeding has done to diversity in Italian durum wheat is very much to be welcomed.

The researchers used molecular and biochemical markers to compare genetic diversity among five different groups of durum varieties, ranging from landraces from before 1915, to pure lines derived from landraces in the 30s, to genotypes selected from crosses between local material and CIMMYT lines in the 70s. In general, there was indeed a narrowing of the genetic diversity within these groups over time. In fact, the degree of narrowing was probably underestimated, because only a relatively few of the pre-1915 landraces were still available for analysis. Conserving what is left is all the more important.

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Lactose tolerance: independent origins and strong selective pressure

Michael Kubisch has submitted another post, based on an article in Nature Genetics. Unfortunately the full article and a News and Views piece about it are behind a paywall. However, I’ve done some sleuthing to find a few links that give more details on the story, which I’ve added at the end. As Michael noted, the article is “not about genetic diversity of agricultural species, but how agriculture has affected human genetic diversity”. That’s good enough for us.

The ability to digest lactose, one of the primary carbohydrates in milk, varies widely among adult human populations. In some European countries nearly 90% of individuals can tolerate lactose, while the incidence in some Asian countries is as low as 1%. The inability to digest lactose is caused by a decline in lactase, the enzyme that breaks down lactose into sugars that can be absorbed into the blood stream. This decline starts shortly after weaning and most likely reflects the fact that until animals were domesticated, milk was simply not a staple of human diets. Lactose tolerance, or lactase persistence as it is sometimes called, in turn is facilitated by a continuous production of lactase throughout adulthood. Not surprisingly, lactase persistence appears to be closely linked to whether a population has traditionally practiced a pastoral or an agricultural lifestyle.

This new study examined the incidence of lactase persistence in several African populations. Based on analysis of genetic markers the authors of the study conclude that the trait appears to have evolved not only independently from Europe, but also more than once in Africa itself. Given that the prevalence of the trait is so high in some populations and domestication of milk-producing animals only goes back 12000 years or so, which is a mere blink of an eye in evolutionary times, milk consumption must have provided a significant benefit for human survival.

Those links:

 

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Hai chihuahua!

A DNA study suggests that small dogs started to appear about 10,000 years ago as a result of a mutation in a single gene (called IGF-1). I wonder if something similar will be found in other domestic animals.

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Reindeer, caribou, genetics and global warming

Reindeer (Rangifer tarandus tarandus) were domesticated probably around 20,000 years ago in northern Europe and Asia. They are still kept by many herders in the Eurasian Arctic, who derive their livelihood from their animals. Reindeer from Siberia were imported into Alaska in the late 19th century in an attempt to provide income for indigenous people. In the 1930s an estimated 600,000 reindeer existed in Alaska, but that number is now down to about 20,000. It seems that most people didn’t quite see the point of managing reindeer when all they had to do was go out and hunt its wild cousin, the caribou (Rangifer tarandus granti). One of the unforeseen consequences of this endeavor has been the migration of reindeer into caribou herds and until recently it was unknown to what extent this influx has had an impact on the genetic diversity of caribou. A recent analysis of microsatellite DNA in caribou and reindeer in Alaska, however, shows that very little genetic introgression seems to have taken place into either species and the authors think the reason could be that hybrid offspring may have a lower chance of survival. It is interesting to note that their study also indicates that the Alaskan/Russian reindeer and the Alaskan and Canadian caribou are much more closely related to each other than either is to the Scandinavian reindeer.

Caribou, which can be found throughout Alaska and the Canadian territories, migrate often in large herds between their summer and winter pastures. The porcupine herd, for example, numbers in excess of 100,000 animals and covers a distance of over 2000 km on its yearly route from the Yukon to the calving grounds on the Alaskan Arctic coast (the very same area the US government is trying to open up for oil exploration).  Many native people in Canada and Alaska still depend on these animals for their survival and they are becoming concerned that increasing human development and global warming may either affect the size of caribou herds or change their migration patterns.

From Michael Kubisch